Crystallography of Biological Macromolecules
نویسندگان
چکیده
C218 located at the interface between A-band and M-line. It has been shown by Centner et al. [2] that MURF-1, a member of the RING finger proteins, binds to the two Ig-domains A168 and A169 in proximity to the kinase. Thus, its binding might be involved in the regulation of titin kinase. The structure of this tandem Ig domain has been solved. Ig domains, also in titin, are involved in many protein-protein interactions and this interconnects titin with other muscle proteins and pathways. Here, we will present new structures near titin kinase and from a downstream signaling pathway of titin kinase (Gautel et al., unpublished data).
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